Two orphans. One barn. And a community in need of miracles. Linney needs protecting, and Louis is the only one left to save her. She may be his big sister, but her Down Syndrome will get her put in an institution if he doesn't hide her well. Only, it's getting harder and harder to pretend he's older than 10 and to keep her safe and warm in this old storage barn. Especially at Christmas, when all his sister wants is a tree with lights, like the one at the church next door. Pageant preparations are in full swing, and Annie Mac and her crew are involved in the excitement. So is Lieutenant Clay Dougherty, her kids' faux-father and the man who still makes her yearn for a whole lot more than she's comfortable offering, especially when she's plagued by crazy-making nightmares. In this heartwarming tale of magic and miracles, the Beaufort, North Carolina, folk return to rescue more than themselves. 1. Language: English. Narrator: Laura Jennings. Audio sample: http://samples.audible.de/bk/acx0/083583/bk_acx0_083583_sample.mp3. Digital audiobook in aax.
A collection of highly imaginative short pieces that speak to our times with deadly accuracy. Vintage Atwood creativity, intelligence, and humor: think Alias Grace. Margaret Atwood turns to short fiction for the first time since her 2006 collection, Moral Disorder, with nine tales of acute psychological insight and turbulent relationships bringing to mind her award-winning 1996 novel, Alias Grace. A recently widowed fantasy writer is guided through a stormy winter evening by the voice of her late husband in "Alphinland," the first of three loosely linked stories about the romantic geometries of a group of writers and artists. In "The Freeze-Dried Bridegroom," a man who bids on an auctioned storage space has a surprise. In "Lusus Naturae," a woman born with a genetic abnormality is mistaken for a vampire. In "Torching the Dusties," an elderly lady with Charles Bonnet syndrome comes to terms with the little people she keeps seeing, while a newly formed populist group gathers to burn down her retirement residence. And in "Stone Mattress," a long-ago crime is avenged in the Arctic via a 1.9 billion-year-old stromatolite. In these nine tales, Margaret Atwood is at the top of her darkly humorous and seriously playful game. List of Stories and Narrators: "Alphinland" and "Torching the Dusties" read by Lorna Raver "Revenant" read by Mark Bramhall "Dark Lady" and "The Dead Hand Loves You" read by Arthur Morey "Lusus Naturae" read by Emily Rankin "The Freeze-Dried Groom" read by Rob Delaney "I Dream of Zenia with the Bright Red Teeth" read by Bernadette Dunne "Stone Mattress" read by Margaret Atwood 1. Language: English. Narrator: Margaret Atwood, Rob Delaney, Mark Bramhall, Lorna Raver, Arthur Morey, Emily Rankin, Bernadette Dunne. Audio sample: http://samples.audible.de/bk/rand/003985/bk_rand_003985_sample.mp3. Digital audiobook in aax.
There are two types of fat storage which represents about 80% of all body fat: visceral which is more pathogenic, and subcutaneous. Distribution of fat, differ according to sex and ethnicity. Both 'apple' and 'pear' shaped distribution can be found in either gender. Female lower body fat is less metabolically active. Exercise seems to result in more subcutaneous fat loss. Diet alone results in more visceral fat loss. Moreover, body fat% appears to be lower in black African children, and higher among Asian races and Hispanics compared with Caucasians. Obesity defined as pathological excess body fat. In children, it leads to decrease in muscle mass which affects children growth, and early occurrence of metabolic syndrome. It also tracks to adulthood obesity. Although BMI is the most popular method for assessment of obesity, it fails to give an idea about body fat distribution. The abdominal fat is more important to be assessed than the total body fat. So, use of other anthropometric methods to assess body fatness is more informative, such as skinfold thickness, waist circumference and body composition .This book give scientific knowledge to the public, particularly the obese.
Insulin resistance (IR) is the condition in which normal amounts of insulin are inadequate to produce a normal insulin response from fat, muscle and liver cells. Insulin resistance in fat cells reduces the effects of insulin and results in elevated hydrolysis of stored triglycerides in the absence of measures which either increase insulin sensitivity or which provide additional insulin. Increased mobilization of stored lipids in these cells elevates free fatty acids in the blood plasma. Insulin resistance in muscle cells reduces glucose uptake (and so local storage of glucose as glycogen), whereas insulin resistance in liver cells results in impaired glycogen synthesis and a failure to suppress glucose production. Elevated blood fatty-acid concentrations (associated with insulin resistance and diabetes mellitus Type 2), reduced muscle glucose uptake, and increased liver glucose production all contribute to elevated blood glucose concentration. High plasma levels of insulin and glucose due to insulin resistance are believed to be the origin of metabolic syndrome and type 2 diabetes, including its complications.
High Quality Content by WIKIPEDIA articles! Wolman disease (also known as Wolman's disease, Wolman's syndrome, and acid lipase deficiency) is a rare autosomal recessive lipid storage disease that is usually fatal at a very young age. It is in the family of lysosomal storage diseases. The defective gene responsible for the disorder is located on chromosome 10.Wolman disease is very rare, with only 50 reports of the disease published in the worldwide medical literature. It affects both males and females and is inherited in an autosomal recessive manner, meaning that a child must inherit two copies of the defective gene, one from each parent, in order to develop the disorder.
The events of September 11, 2001 have clearly demonstrated that the future pathologies of warfare will increasingly affect noncombatant populations on a large scale and require new levels of treatment expertise. In Combat Medicine: Basic and Clinical Research in Military, Trauma, and Emergency Medicine, highly accomplished clinical and basic investigators concisely review the leading research issues confronting emergency and military medicine today. These experts begin by presenting the latest thinking about the molecular and cellular mechanisms of trauma-apoptosis, abnormalities in nitric oxide production, complement activation, and immune cell response to stressors-that lead to tissue damage, and then describe cutting-edge research aimed at understanding and reversing the consequent damage to major organs. The clinical conditions covered include hemorrhagic shock and resuscitation, ischemia-reperfusion injury, acute respiratory distress syndrome, thermal injury, inhalation injury, and traumatic brain injury. The authors discuss the natures of combat pathologies, current research, emerging treatments, red blood cell storage, and bioterrorism involving anthrax, smallpox, plague, and other infectious and toxic agents. Cutting-edge and timely, Combat Medicine: Basic and Clinical Research in Military, Trauma, and Emergency Medicine offers not only clinical and basic investigators, but also surgical and medical residents, a concise introduction to the principal clinical conditions encountered in emergency, disaster, and combat medicine, as well as an up-to-date statement of where our diagnostic and treatment programs now stand, and what we still need to learn for future preparedness.
From one of Canada's most celebrated writers, two-time Giller Prize winner Moyez Vassanji, comes a taut, ingenuous and dynamic novel about a future where eternal life is possible, and identities can be chosen. In the indeterminate future in an unnamed western city, physical impediments to immortality have been overcome. As society approaches the prospect of eternal life, a new problem must be confronted: with the threat of the brain's storage capacity being overwhelmed, people want to move forward into the future free from redundant, unwanted and interfering memories. Rejuvenated bodies require rejuvenated identities--all traces of a person's past are erased and new, complete fictions are implanted in their stead. On occasion, though, cracks emerge, and reminders of discarded lives seep through. Those afflicted suffer from Leaked Memory Syndrome, or Nostalgia, whereby thoughts from a previous existence burrow in the conscious mind threatening to pull sufferers into an internal abyss. Doctor Frank Sina specializes in sealing these memory leaks. He is satisfied in his profession, more or less secure in the life he shares with his much younger lover, content with his own fiction--a happy childhood in the Yukon, an adulthood marked by the influence of a mathematician father and poet mother. But one day, Presley Smith arrives in Frank's office. Persistent thoughts are torturing Presley, recurring images of another time and place. As he tries to save Presley from the onslaught of memory, Frank finds clues that suggest Presley's past may be located in war-torn, nuclear-ravaged Maskinia, a territory located in the southern hemisphere, isolated from the north by fiercely guarded borders and policy barriers. Frank's suspicions are only intensified when the Department of Internal Security takes an interest in Presley. They describe him as one of their own, meaning his new life was one they created for him, and they want him back. Who was Presley before the Department remade him, what secrets are buried in the memories that are encroaching upon him? As Frank tries to save Presley from both internal and external threats, cracks emerge in his own fiction, and the thoughts that sneak through suggest a connection with the mysterious Presley that goes well beyond a doctor and his patient.
The knowledge of lysosomal biology and the consequences of its dysfunction have increased dramatically in the past 60 years. Research of these disorders has moved from diseases with unknown etiology to disorders with clear and defined pathophysiology and some of them have benefited from the development of disease specific therapeutics. Lysosomal Biology and Storage Disorders describes the nature of the diseases, the historical evolution of the field and future perspectives for the treatment of these clinical entities. Organized as a textbook, Lysosomal Biology and Storage Disorders describes the nature of lysosomal dysfunction, the synthesis and targeting of lysosomal enzymes and the implications of the targeting mechanisms for the development of new therapies. Disease specific chapters provide thorough reviews of the clinical features of lysosomal storage disorders, their molecular basis and the commercial or experimental therapeutic approaches sought in this area. TOC:From Lysosomes to Storage Diseases and Back: A Personal Reminiscence.- Lysosomal Biogenesis and Disease.- The Concept of Treatment in Lysosomal Storage Diseases.- Complex Lipid Catabolism.- Retroviral Vectors for Gene Therapy.- Adenovirus in Gene Therapy.- Setting Back the Clock: Adenoviral-Mediated Gene Therapy for Lysosomal Storage Disorders.- Adeno-Associated Viral-Mediated Gene Therapy of Lysosomal Storage Disorders.- Herpes Simplex Virus Vectors for Gene Therapy of Lysomal Storage Disorders.- Gene Therapy of Lysosomal Storage Disorders by Lentiviral Vectors.- Substrate Reduction Therapy.- Newborn Screening for Lysosomal Storage Disorders.- Genetic Counseling for Lysosomal Storage Diseases.- Neural Stem Cell Therapy in Lysosomal Storage Disorders.- The GM1 Gangliosidoses.- The GM2 Gangliosidoses.- Acid Sphingomyelinase-Deficient Niemann-Pick Disease.- Krabbe Disease (Globoid Cell Leukodystrophy).- Metachromatic Leukodystrophy.- Fabry Disease.- Gaucher Disease: Review and Perspectives on Treatment.- Therapeutic Goals in the Treatment of Gaucher Disease.- The Neuronal Ceroid Lipofuscinoses: Clinical Features and Molecular Basis of Disease.- Mucopolysaccharidosis I.- Mucopolysaccharidosis II.- Sanfilippo Syndrome: Clinical Genetic Diagnosis and Therapies.- Mucopolysaccharidosis IV (Morquio Syndrome; MPS IV).- Mucopolysaccharidosis Type VI (MPS VI, Maroteaux-Lamy Syndrome).- Mucopolysaccharidosis Type VII (Sly Disease): Clinical, Genetic Diagnosis and Therapies.- Pompe Disease-Glycogenosis Type II: Acid Maltase Deficiency.- Lysosomal Free Sialic Acid Storage Disorders: Salla Disease and ISSD.- Cystinosis.- I-Cell Disease.
Originally published in 1982, this book brings together two areas of research previously studied in parallel, with little interaction (particularly in the US): normal memory processing and the amnesic syndrome. When trying to document the relationship between the two it became apparent that there was much crossover and duplication of effort in a number of areas: whether long-term memory and short-term memory truly represent independent storage systems, or are simply points on a continuum; trying to determine the primary locus of variables influencing the rate at which information is lost during retention; whether episodic memory and semantic memory represent two different storage systems, or are simply artifacts produced by different kinds of query to a single memory system and finally, whether visual and verbal memory are independent.It was written, following a meeting in 1979, by a small group of investigators, brought together to explore this commonality and to share data and theory, thus beginning the promise of a bright future of interdisciplinary interaction in memory research.